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4 weeks (standard): ~1 vial 8 weeks (standard): ~2 vials 8 weeks (advanced): ~3 vials Insulin Syringes (U-100, 1 mL) Per injection: 1 syringe 4 weeks (once daily): ~30 syringes 8 weeks (once daily): ~60 syringes Bacteriostatic Water (10 mL bottles) Use ~3.0 mL per 45 mg vial for reconstitution

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SIRT1-dependent regulation of chromatin and transcription: linking NAD(+) metabolism and signaling to the control of cellular functions