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doi: 10.1039/C6MB00600K 187 ArmstrongCWMcGregorNRLewisDPButtHLGooleyPR
A SLC39A8 (ZIP8 A391T) variant identified in genome-wide studies disrupts the regulation of multiple metals, including Mn, and increases susceptibility to Crohns disease ( Zip8 KO mice exhibit systemic Mn deficiency and aggravated colitis, which can be rescued by inhibition of the downstream sphingolipid enzyme ACER1 ( Mn metabolism is also shaped by immune-mediated metal redistribution through nutritional immunity
Therefore, we commonly regard the expression of PGC1 , NRF1 , TFAM , and mitochondrial-related genes, as well as mtDNA copy number as the markers for mitochondrial biogenesis
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