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Phase II Conjugation Glutathione binds to these intermediates through conjugation the crucial step that makes toxins water-soluble

Outcomes differ by dose, route (including intravenous glutathione), cofactors like ascorbic acid, baseline skin pigmentation, and dark spots

For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission

10.1016/j.canlet.2015.04.020 227 Rabanal-RuizY.OttenE

Thus, urinary citrate protects against calcium oxalate and uric acid kidney stones

This antagonistic effect of polyphenols has been previously observed by Lui et al