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Network analysis of microbial co-occurrence patterns Network analysis across taxonomic levels revealed key microbial interactions and potential keystone taxa (Figure S6)

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462 Mitochondrial dysfunction, mtDNA instability, and impaired mitophagy Mitochondria are essential regulators of immune signaling, apoptosis, metabolism, and stress responses

The Firmicutes to Bactereoidetes ratio is significantly higher in persons at risk for cardiovascular disease, in which Prevotella and Klebsiella species are abundant in assessing the fecal microbiota of atherosclerotic CVD patients (238)