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Although the triptans are arguably the most effective treatment for acute relief of a migraine headache (i.e., the "gold standard"), they have a number of side effects (Cady 2011)

Common & Lesser-Known Clinical Uses Common Uses: Fever reduction Headaches Muscle pain Joint pain (Osteoarthritis) Menstrual cramps (Dysmenorrhea) Expert Insight: Clinical studies show that Nimesulide offers fast relief, often working within 30 minutes of ingestion, making it ideal for acute pain where rapid action is needed

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The Centers for Disease Control and Prevention (CDC) states that if a multi-dose vial has been opened or accessed (e.g., needle-punctured) the vial should be dated and discarded within 28 days unless the manufacturer specifies a different (shorter or longer) date for that opened vial