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Tolerability and Safety Questions Both candidates are likely to be judged partly on gastrointestinal tolerability: nausea, vomiting, diarrhea, constipation, dose escalation, and discontinuation due to adverse events

Fletcher MM, Belousoff MJ, Harikumar KG, et al

Molecular evidence for BDNF- and GABA-related dysfunctions in the amygdala of female subjects with major depression

It is undergoing Phase III trials to evaluate its safety in treating DED caused by dry eye syndrome (NCT05310422 and NCT04819269)

(PubMed) Leach NV, Dronca E, Vesa SC, et al

Both medications have similar side effects, drug interactions, and precautions