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It should also be avoided in patients with certain medical conditions such as Lebers disease or cobalt allergy

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Statistical significance was determined by one-way repeated measures analysis of variance

Other mechanisms include increased insulin resistance induced by high-dose glucocorticoids that increases intra-portal insulin, decreases IGFBP-1 that increases free IGF-I, and direct glucocorticoid effects in increasing hepatic IGF-I synthesis and decreasing hepatic insulin clearance (105)

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