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In the early stages of OA, proliferating chondrocytes disrupt ECM composition, resulting in reduced proteoglycan synthesis and altered matrix permeability and mechanical compliance (Sun et al., 2012)

They are usually induced by corticosteroids, anti-tubercular drugs, anticonvulsivants, antipsychotics and some anti-cancer agents [1]

Hydropersulfides are thought to mediate many of the antioxidant signaling functions once ascribed purely to hydrogen sulfide via modification of protein cysteine (Cys) residues in a process referred to as persulfidation

Stay as hydrated as possible in the days leading up to your appointment

Skoulidis et al, 2021)

This process is primarily executed by members of the gasdermin family, most notably gasdermin D (GSDMD), which is activated by inflammatory caspases in both canonical and non-canonical inflammasome pathways 51