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Tofacitinib is a non-selective JAK inhibitor (targeting JAK1/2/3/TYK2) that has been approved by the food and drug administration (FDA) for the induction and maintenance of remission in moderate to severe UC, particularly in patients who have failed traditional immunomodulators or biologic agents [348, 351]

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the GSH group up-regulated 17 differential metabolites and down-regulated 16 differential metabolites relative to the NC group

It helps the liver process and eliminate toxins by binding to harmful substances and making them water-soluble for easier elimination

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