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(2025) addressed this question directly in a comprehensive review

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Orthostatic intolerance will impact on the patients ability to adopt certain positions and move quickly between positions

Once these receptors recognise a fungus, they trigger signaling cascades (such as the SYK-CARD9, MYD88, TRIF pathways) to produce cytokines, e.g ., IL-1, IL-6, IL-12, IL-23, transforming growth factor- (TGF-1), and interferon-, which induce IL-17A production by Th 17 and Th1 cells 18,121

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Sasaki et al