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Protection Against Oxidative Tissue Injury Beyond biochemical markers, structural tissue outcomes further reinforce the relevance of antioxidants

FIGURE 2 5.1 Exercise regulates iron metabolism Iron levels in specific organs such as the brain, skeletal muscles, intestines, and liver gradually increase with age (Chen and Xiao, 2014

In preclinical models that simulate stress-induced depression, supplementation with Ashwagandha has been shown to markedly reduce the release of cytokines, restore antioxidant defenses (e.g., glutathione, superoxide dismutase), and lower markers indicative of oxidative stress (82)

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GSTs are known to degrade biphenyl, but no specific activity of GST in Lb

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