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Obesity, alcohol abuse, cigarette smoking, and heavy metals have been firmly linked with OS

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doi: 10.1016/j.plaphy.2020.11.035 47 WangJ.ZhangY.YanX.GuoJ

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In contrast R proteins bind cobalamin less avidly and undergo proteolysis when they come into exposure to the more alkaline environment of the small intestine (SI) (72)