stimulated RA-FLSs with IL-1 and reported that it significantly promoted cell proliferation and cellular inflammatory responses
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Mao J, Zhang H, Luo J, et al
Lifestyle interventions (including diet, exercise and behavioural changes) are the cornerstone of obesity management with diverse benefits, but even the most intensive lifestyle interventions result in up to 10% mean weight loss (WL) and weight maintenance remains a challenge, as 80% of WL is expected to be regained over the next 5 years [4, 5]
In RA, synovial macrophages and T cells excessively secrete TNF-, driving synovial hyperplasia and inducing IL-6 and IL-1 release, which forms an inflammatory amplification loop and leads to cartilage and bone destruction (66)
doi: 10.1089/ars.2011.4391 9 LinWWangCLiuGBiCWangXZhouQet al