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GLP-1 exerts anorexigenic effects through the GLP-1 receptor (GLP-1R), which is widely distributed in the brain, GI tract, and pancreas [48]
Its specific target is the regeneration of brain cells in the cerebral cortex, the outer layer of the brain responsible for higher cognitive functions including reasoning, language, planning, and sensory processing
Interestingly, BDNF levels were found to increase after PUFA supplementation in mice, which may mediate PUFA-induced neurogenesis in the hippocampus [191]
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Heres a comparison of potential approaches for study design: Ultimately, the optimal strategy depends on the specific goals of the research