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Par consquent, le pourcentage qui atteint gnralement la cellule hpatique est particulirement faible

There are two parts to this: the intrinsic low solubility of niclosamide in aqueous solution compared to its efficacy

Hepatic effects that are considered adverse include death, abnormal clinical chemistry parameters, obvious functional organ impairment, DNA and mitochondrial alteration, glutathione depletion, hepatocyte necrosis, enhanced replicative DNA synthesis, generation of reactive oxygen species, and increased peroxisome proliferation (in rodents) (Williams and Iatropoulos 2002)

On the other hand, this toxicity response to AFB 1 is proven by a significant increase in LDH and cardiac troponins leakage from BCMs, as sensitive markers for acute cardiac damage (133)