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About this article Cite this article Sanz, A.B., Sanchez-Nio, M.D., Ramos, A.M

The rationale for study quality ratings are available on Tableau on the study quality evaluation heatmap tab: Evidence Synthesis and Integration Syntheses of the evidence for epidemiologic and animal toxicological health effects were based on high and medium confidence studies when possible

Fix: Start with 2030 mcg/day and assess tolerance over 12 weeks

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Drug-Induced Liver Injury (DILI) Liver is the main target organ of drug toxicity, because it acts a crucial part in human drug metabolism and clearance

Abbreviations AASLD: American Association for the Study of Liver Diseases CGA-HE: Clinical Global Assessment of Hepatic Encephalopathy CI: confidence interval EASL: European Association for the Study of the Liver FMT: fecal microbiota transplantation GABA: gamma aminobutyric acid GPB: glycerol phenylbutyrate HAS: hepatic encephalopathy scoring algorithm HE: hepatic encephalopathy HR: hazard ratio LOLA: L-ornithine L-aspartate NAD: non-absorbable disaccharides NNT: number needed to treat OR: odds ratio PAA: phenylacetic acid PBA: phenylbutyric acid PEG: polyethylene glycol PHES: Psychometric HE-score RBANS: Repeatable Battery for the Assessment of Neuropsychological Status RCT: randomized clinical trial RR: relative risk SCFA: short-chain fatty acid SOC: standard of care TIPS: transjugular intrahepatic portosystemic shunt WHS: West Haven scale Declarations Acknowledgement This work was made possible by the Herman Lopata Chair in Hepatitis Research