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Curr Opin Immunol 20:288294 Tepper RI, Coffman RL, Leder P (1992) An eosinophil-dependent mechanism for the antitumor effect of interleukin-4

Chemical compatibility with glutathione and glutathione agarose beads

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And a C18 fatty diacid chain attached at position 26 allows the peptide to bind to albumin in the bloodstream, which slows its clearance and gives it a half-life of approximately seven days

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To interrogate whether melatonin could restrain ILC2 effector function we employed an adoptive transfer model, whereby activated ILC2s were isolated from Rag2 -/- mice, cultured for 24h in the presence or absence of melatonin, and then adoptively transferred the ILC2s into Rag2 -/- GC -/- mice utilizing established protocol as described by our group previously (48, 49) ( Figure 4A )