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However, to our knowledge there have been no studies of growth factors tested in animal models with naturally occurring IVD degeneration

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AGER-mediated STAT3 activation induces fatty acid oxidation, causing long-chain fatty acids to break down into acetyl-CoA, polarizing macrophages into an M2-like tumor-promoting phenotype

What the evidence does not support Large-scale human clinical trials confirming safety and efficacy have not been published