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In SURMOUNT-1 , a 72-week Phase 3 double-blind trial in 2,539 adults with obesity (or overweight with a complication) but without diabetes, once-weekly tirzepatide produced mean weight changes of 15.0% (5 mg), 19.5% (10 mg), and 20.9% (15 mg) versus 3.1% with placebo, with 5057% of participants on the higher doses losing at least 20% of body weight

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The beneficial effects of hyaluronidase-1 blockade are closely related to activation of the 5-AMP-activated protein kinase/mechanistic target of rapamycin (AMPK/mTOR) signaling pathway (141)