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The high efficiency of superoxide dismutase seems necessary: even at the subnanomolar concentrations achieved by the high concentrations of SOD within cells, superoxide inactivates the citric acid cycle enzyme aconitase, can poison energy metabolism, and releases potentially toxic iron

One study found a correlation between BA levels and fibrosis in HBV [79], but overall, this examination seems underutilized

The Importance of Metabolism Besides dose, what your body does with a particular substance, how it gets metabolized and the biologic effect those metabolites exert are all critical factors in determining if that substance is truly friend or foe

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Biochem J 227:629638 Preston GA, Zarella CS, Pendergraft WFr, et al

Increased G6PD activity, which is the gatekeeping enzyme of the pentose phosphate pathway [69], and xanthine suggest an increased turnover rate for purine nucleosides, which may arise from the increased DNA damage from continuous exposure to tamoxifen