The typical outcome measure used by researchers is the Sciatic Function Index that assesses hind limb motor function based on toe to toe and toe to heel distance
Short answer
Damaged AECs release pro-inflammatory and pro-fibrotic mediators, including interleukin (IL) -1 and tumor necrosis factor (TNF) -, which promote fibroblast recruitment, inflammatory cell activation (e.g., neutrophils, Th17, gdT cells), and myofibroblast differentiation, ultimately leading to ECM accumulation and fibrotic tissue remodeling [20, 29, 33, 34]
Disease Prevention Aging According to the free radical and mitochondrial theories of aging, oxidative damage of cell structures by reactive oxygen species (ROS) plays an important role in the functional declines that accompany aging (14)
Start with a lower concentration (around 10%), patch-test before full use, and introduce products gradually
For every online anecdote about a devotee who lost 50 pounds on the Bulletproof Diet, there seems to be someone else who received alarming results on their lipid panels after they began putting two tablespoons of butter in their coffee every morning
