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BPC-157 demonstrates exceptional safety in animal toxicology studies, with comprehensive evaluations in mice, rats, rabbits, and dogs failing to establish a lethal dose (LD) across wide dose ranges extending from standard research doses (6 g/kg) to levels exceeding 1000-fold higher concentrations (20 mg/kg), with no evidence of acute toxicity, organ-specific damage, or systemic adverse effects even following repeated high-dose administration

(2018, October 17)

Long-term controlled safety data are absent

Self-running a protocol means none of that feedback exists

Fibronectin can bind to integrins such as 51, 3, 5 (101) and ED-A-FN is associated with myofibroblasts and OA (77)

I initially thought hEDS was rare, because all forms of EDS are commonly referred to as rare