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Notably, these studies also established that the mode of administration (IP versus oral) did not influence the radio-mitigative activity of DSePA against RP
The challenges faced by the nanomaterials in the process of clinical translation are highly complex due to the fate of nanomaterials in vivo, specifically stability issues as it is exposed to various biological systems, safety/toxicity issues due to bio-accumulation of non-degradable materials, and so on
Alkylating agent-induced NRF2 blocks endoplasmic reticulum stress-mediated apoptosis via control of glutathione pools and protein thiol homeostasis
[cited 2023 June 30] 45
& Malamud, N
GA caused multiple forms of cell death, such as apoptosis characterized by mitochondrial cytochrome c release and caspase-3 activation, ferroptosis characterized by lipid peroxidation, and necroptosis characterized by loss of plasma membrane integrity, in an iron-dependent manner (Tang and Cheung, 2019)
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