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In contrast, unconstrained swelling significantly increased matrix distortion, glycosaminoglycan loss, exposure of integrin binding sites, expression of MMPs 1 and 3, and collagen denaturation

References 1 AlbanisE.FriedmanS

That matters clinically because tendon and ligament recovery depends heavily on cellular repair activity, collagen organization, vascular support, and the ability to gradually reload tissue

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It is thought that TT not only restricts blood flow to the testis but also disrupts circulation to the epididymis 3