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Our study is first to demonstrate novel molecular mechanisms involved in the sensitization of PTC cells to ferroptosis inducer- we show that RSL3, a potent direct GPX4 inhibitor, effectively reduces the viability of thyroid cancer lines with various mutational backgrounds compared to HThF control cell line in a dose-dependent manner

doi: 10.3389/fphar.2014.00038

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ESPEN 124 ZawilskaJ.SkeneD.ArendtJ

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GSH may have decreased due to side reactions with amino groups during sample pretreatment