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114 Sufficient evidence for the cholesterol-lowering effects of sterols prompted the U.S

Statements Author contributions WritingOriginal draft preparation: WF and ZY

discovered that lactate, produced through glycolysis in pancreatic ductal adenocarcinoma (PDAC), can promote H3K18la under the catalysis of P300, thereby enhancing the transcription of mitotic checkpoint regulatory factors TTK and BUB1B

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However, in line with the AOP framework, these high-dose studies remain valuable for identifying key biological events and guiding further research at environmentally relevant exposures

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