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Catechin hydrate directly inhibits macrophage RasGRP1, a pro-inflammatory gene in macrophages, thereby diminishing excessive inflammation and oxidative stress that contribute to numerous organ dysfunctions resulting from sepsis (278)
In addition, tubular epithelial cell apoptosis was alleviated in LPS-induced acute kidney injury by decreasing ROS production (Golz et al., 2014)
The absence of GGT activity on the apical surface of the kidneys proximal tubules by genetic disorder results in glutathionuria [29,30]