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Doxycycline commonly causes nausea and stomach upset, which can be reduced by taking the medication with food

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10.1007/978-1-0716-3662-6_27 343 NicholK

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Because it does not cross the blood-brain barrier easily and acts primarily on peripheral fat tissue, it is viewed as a highly targeted fat-loss agent with minimal central nervous system side effects

We isolated pancreatic islets from WT and GCGR-KO mice and assessed the glucagon secretion under varying glucose concentrations