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Expert Rev Anti-Infect Ther

Data on urate-lowering medicine dispensings in Part B includes patients dispensed at least one of benzbromarone, febuxostat, allopurinol or probenecid

doi:10.1124/jpet.112.199497 [ Notice of Concern issued September 2021

While demonstrating biological plausibility and mechanisms, in vitro conditions poorly replicate complex in vivo environment

From a biochemical perspective, its quite unusual because it exists naturally in both free and bound forms

Samples were measured on an Orbitrap Eclipse (Thermo Fisher Scientific) with an Easy-nLC 1200 (Thermo Fisher Scientific) using a 180-minute gradient consisting of 2%23% ACN, 0.125% FA, at 500 nL/min flow rate