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Biochem Biophys Res Communic 304:385392

798,799 Intravenous injection of histochrome significantly reduces cardiac fibrosis, increases capillary density, and significantly improves cardiac function in I/R rats by upregulating the expression of Nrf2 and its downstream genes, including GPX4, and reducing intracellular and mitochondrial ROS levels

enhanced nitrogen retention

Studies have shown that DCA upregulates the expression of hypoxia-inducible factor-2 (HIF-2) and divalent metal transporter-1 (DMT1), leading to the accumulation of ferrous ions, which enhances lipid peroxidation within cells and promotes the onset of ferroptosis (Wang et al., 2024a)

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