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Although often presented as a broadly beneficial polyphenol, resveratrol has also been repeatedly flagged as a potentially PAINS-susceptible molecule, owing to its redox activity, metal-chelating properties, and tendency to interfere with multiple assay formats in a non-specific manner as highlighted in the Nature commentary (Baell, 2016)

doi: 10.1038/cr.2010.52 51 Schulze-OsthoffKRisauWVollmerESorgC

It works by inhibiting NNMT, an enzyme that regulates cellular energy metabolism and is mostly found in fat tissue

This is why many skincare and health experts recommend pairing them

thus the engineered hydrogel is named as self-diagnostic that can be used to alter wound microenvironment to promote wound healing in an intelligent manner [179]

Biochem J 104(2):627