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Moreover, other studies indicated that a combination of 400 g/d B12 with 2 mg/d folic acid and 25 mg/d vitamin B6 for 6 months, resulted in reduced homocysteine levels, severity, and disability of migraine attacks (54, 60)

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References Nagai, S

In addition, it is thought that the mechanisms that ensure PQC in the nucleus are distinct from those of other organelles [108, 109], an example being the exclusive use of K48-linked ubiquitin chains required for proteasomal degradation of misfolded proteins, and thus independency of K11-specific ligases and chaperones [110]