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People who regularly take metformin, proton pump inhibitors, and H2 blockers, or have gastrointestinal disease are also at increased risk

Technically, this is a "lightening" effect

It is the acetylated heptapeptide Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln, corresponding to residues 17-23 of native T4 (43 amino acids)

doi:10.1016/j.physbeh.2019.112676 Donelli D, Antonelli M, Bellinazzi C, Gensini GF, Firenzuoli F

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A research protocol may test a substance under close supervision, with specific eligibility criteria and controlled preparation