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720 Cerebral ischemia also increases levels of circulating iron-carrying transferrin in ischemic brain tissue, enhancing ROS induced neuronal death

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they are separated into four groups and placed into four sterilizer cages, each with seven mice and placed in a room of 2125C temperature and 12-h light/dark cycles

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Pharmacological targeting of CHAC1-mediated processes therefore represents a rational therapeutic strategy, potentially disrupting the cycle of GSH depletion, ER stress amplification and iron-dependent peroxidation that drives neuronal loss