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The sATF6 protein then translocates to the nucleus and mediates apoptosis by promoting CHOP expression (Liang et al., 2020)

Published online November 14, 2024

Intracellular ROS homeostasis is characterized by the ability of cells to adapt to changing conditions such as hypoxia, hyperoxia, and oxidative stress [4,5,6], while disruptions in this equilibrium can have significant implications for cell fate [7], disease progression [8], and therapeutic responses [9]

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It appears to modulate glutamate levels in the brain, the most abundant neurotransmitter, which, in excess, can cause neurotoxicity and contribute to the development of neurological disorders

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