Notably, no bacteria were observed in contact with the ependymal epithelium of the choroid plexuses, suggesting that meningococcus does not cross this barrier (Dando et al., 2014)
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doi: 10.1073/pnas.0712245105 41 KchEMVellaramkalayilRZhangILehnenDBrggerBSreemmelWet al
In animal models, targeting lactate metabolism (such as inhibiting LDHA or B7-H3) significantly suppresses tumor growth and activates tumor-infiltrating CD8 + T cells, providing a new strategy for combined immunotherapy (98) ( Figure 2 )
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Weight loss driven by tirzepatide compounds this benefit, as even modest weight loss reduces liver fat