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The peptide upregulates MMP-2 expression in dermal fibroblasts by 85%, facilitating breakdown of damaged collagen and enabling cellular migration through dense matrix environments, while simultaneously enhancing production of tissue inhibitors of metalloproteinases (TIMPs) to prevent excessive degradation

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Metseras recent announcement of positive Phase 2b data for MET-097i a First- and Best-in-Class Ultra-long Acting GLP-1 RA candidate marks an important step forward, with Phase 3 expected to begin in 2025