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While additional studies are needed to determine whether elevated vitamin B 12 status may be related to cancer development, including evaluating whether it might be a potential marker of cancer, it is important for observational studies to adequately control for potential confounders, such as age, menopausal status, alcohol use, and intake of the B-vitamin folate

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The underlying cause of deficiency is the most important determinant

Most research-context use is oral capsules at 50 to 150 mg per day

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