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Parkinsons disease Parkinsons disease (PD) is a long-term neurodegenerative disorder that affects the motor system, characterized primarily by the death of dopaminergic neurons in the substantia nigra and the presence of intracellular aggregates of misfolded -synucleine (Lewy bodies) in the surviving neurons 54,55

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[ref][ref][ref][ref] Brain atrophy: High homocysteine is associated with brain atrophy and cognitive decline in aging

4.2 Shared epigenetic abnormalities in HT and CD Epigenetic abnormalities have been reported in both disorders

Ibrahim IA, Shalaby AA, Abd Elaziz RT, Bahr HI

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