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PMID: 20552409

The primary contribution to the barrier function belongs to the BBB since at the level of brain micro-vessel endothelium BBB is the major site of blood-CNS exchange (Abbott et al., 2010)

Treatment includes Gene therapy and Orexin cell Transplantation

Bean J, Brennan C, Shih J-Y, Riely G, Viale A, Wang L, Chitale D, Motoi N, Szoke J, Broderick S, Balak M, Chang W-C, Yu C-J, Gazdar A, Pass H, Rusch V, Gerald W, Huang S-F, Yang P-C, Miller V, Ladanyi M, Yang C-H and Pao W (2007) MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib

Mechanism of metformin-dependent inhibition of mammalian target of rapamycin (mtor) and ras activity in pancreatic cancer: Role of specificity protein (sp) transcription factors