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The FDA's primary mandate is to protect public health by ensuring that all drugs, including compounded medications, are safe and effective for their intended uses

doi: 10.4161/cc.20153

For knee osteoarthritis specifically, injectable hydrolyzed collagen (ChondroGrid) shows impressive resultssignificant improvements in pain, stiffness, and function scores after just 30 days of treatment (with statistical significance of p=0.030.04)

Gastroenterology 119 , 10291036 (2000)

Unreconstituted powder should be kept in a cool, dark place and can be refrigerated for extended shelf life