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XL184 is useful at low concentration (0.10.5 M) to induce marked inhibition of constitutive and inducible c-Met phosphorylation and its consecutive downstream signaling in malignant peripheral nerve sheath tumor cells

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10.1101/2025.01.14.633073 180 Van PeltK

By blocking this enzyme, the molecule preserves the cellular NAD+ pool, supports sirtuin activation, and stimulates energy expenditure through improved mitochondrial function

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