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Problem two: the dose-response curve was reported as bell-shaped Scherschlicht and colleagues at Roche studied synthetic DSIP in rabbits, cats, and morphine-dependent mice

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*Correspondence: Min Tang, [email protected] These authors share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Comprehensive automation for NMR structure determination of proteins