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By selectively inhibiting NNMT an enzyme central to energy regulation and fat metabolism this compound has demonstrated, in preclinical studies, the capacity to elevate intracellular NAD and SAM levels, suppress lipid accumulation in adipocytes, and reduce white adipose tissue mass in diet-induced obese mouse models

Despite its importance, B12 deficiency is remarkably common particularly among vegetarians, older adults, individuals with digestive conditions, and anyone whose body has difficulty absorbing this vitamin from food or oral supplements

[24] Due to its hormonal activity and lack of safety data, breastfeeding during treatment with HCG is not advised

You may also have a higher risk of developing a vitamin B12 deficiency if: If youre experiencing any of the following symptoms, you may have a vitamin B12 deficiency

Patients with a history of thrombocytopenia or any other hematologic disorder should also avoid using this formulation

You may wish to ask your GP the following questions: Has my B12 level been checked recently , particularly if I have been on metformin for more than a year, or if I have symptoms or risk factors for deficiency