The following articles explain your genetic susceptibility variants related to phase II detoxification, nutrients and cofactors needed for optimal support, and how to prioritize what is most important for you, personally, to avoid.[ref] Nrf2 Signaling Pathway master switch inducing the phase II enzyme pathways, upregulated by sulforaphane [ref] UGT genes glucuronidation, most prevalent phase II enzyme GST genes glutathione conjugation reactions SULT genes sulfation reaction increases the water solubility of drugs, hormones, and xenobiotics
Avoiding hard, chewy foods for 7-10 days while applying moist heat for 15-20 minutes several times daily can significantly reduce symptoms and prevent further joint irritation
doi: 10.1158/1078-0432.CCR-15-0487 119 LiuJDengHJiaWZengYRaoNLiSet al
If you're on the fence about getting your hormones checked, my advice is simple: do it
143 Transcription factor nuclear protein 1(NUPR1) has been reported to transfer lipocalin 2 (LCN2) and block ferroptosis by reducing iron accumulation
American journal of physiology Renal physiology
