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Acknowledgements We would like to thank Instituto do Osso e da Cartilagem for the support and Jos Fbio Lana for his remarkable academic contributions towards the production of this manuscript

Essential Functions of Vitamin B12 in the Body Vitamin B12 is vital for many body functions

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Singh R, Kashyap S, Singh V, Kayastha AM, Mishra H, Saxena PS, Srivastava A, Singh RK (2018) QPRTase modified N-doped carbon quantum dots: a fluorescent bioprobe for selective detection of neurotoxin quinolinic acid in human serum

Free radicals were first recognized in biological systems in the 1950s and it was assumed that they are engaged in aging and several other pathological conditions [30]

Gliotoxin isolated from marine fungus Aspergillus sp