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In conclusion, this paper study highlights the role of PDFV and VCAM-1, the precursor protein of PDFV, in OvE disease progression

The peptide displayed a very good safety and tolerability profile indistinguishable from placebo, with no treatment-related serious adverse events or study withdrawals

Human and canine patients with IVD degeneration can thus be used as a study population to investigate the mechanisms of degeneration and potential regenerative treatments, which is beneficial for both species and suits the 'One Health concept

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