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Newer imaging modalities, such as oxygen uptake fraction measurements, transcranial Doppler ultrasound, and magnetoencephalography, can provide additional insight into the affected brain tissue and aid in prognosis prediction (31)

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Therefore, in IBD, in addition to providing in situ retention and sustained-release protection, it is also necessary to have certain oral stability, mucosal adhesion and inflammatory site targeting, so as to ensure the stability and local effective concentration of nanozym-hydrogel in the complex intestinal environment [145-147]