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Preclinical and observational data suggest that side effects primarily depend on dosage, frequency, and individual metabolic response

doi:10.1073/pnas.261469998

In its May 2026 evaluation, the FDA identified one small meeting abstract describing a short randomized study in people with ulcerative colitis

For individuals who cannot absorb enough vitamin B12 from food sources alone, injectable supplementation provides a dependable way to restore and maintain adequate levels

2 However, the contribution of other anaemia causes, such as blood loss, may be underestimated in certain regions due to limitations in available reliable data