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The microchannels created by needling allow the peptide to bypass the skin barrier and penetrate directly into the dermis dramatically increasing absorption compared to surface application alone

doi: 10.1038/s41392-024-01881-6 51 KeatingsVMCollinsPDScottDMBarnesPJ

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When GSH becomes oxidized, a disulfide bond forms between two GSH molecules, which become oxidized glutathione (GSSG)

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